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Ibyiciro by'ibicuruzwa
Ibicuruzwa byagaragaye
01
HPMC yo mu rwego rw'imiti
HPMC yo mu rwego rw'imiti
HPMC yo mu rwego rw'imiti
HPMC yo mu rwego rw'imiti
HPMC yo mu rwego rw'imiti
HPMC yo mu rwego rw'imiti
HPMC yo mu rwego rw'imiti
HPMC yo mu rwego rw'imiti
HPMC yo mu rwego rw'imiti
HPMC yo mu rwego rw'imiti

HPMC yo mu rwego rw'imiti

HPMC Hydroxypropyl methylcellulose yo mu rwego rwa farumasi ni umweru cyangwa umweru w’amata, nta mpumuro, nta buryohe, nta furu cyangwa granule bifite fibro, kugabanya ibiro iyo byumye ntibirenze 10%, bishonga mu mazi akonje ariko ntibishonga mu mazi ashyushye, buhoro buhoro mu mazi ashyushye. Kubyimba, gusohora, no gukora umuti wa colloidal umeze nk'umuti, uba umuti iyo ukonje, kandi ukaba gel iyo ushyushye.


Hydroxypropyl Methylcellulose (HPMC) ni ubwoko bwihariye bwa HPMC bukoreshwa mu nganda zikora imiti. HPMC ni polymeri ishongesha amazi ikomoka kuri selulose, kandi iyo ikoreshejwe mu miti, itanga inyungu nyinshi n'ikoreshwa ryayo.

    Twandikire
    ibisobanuro birambuye ku bicuruzwa

    Ibisobanuro by'imiti

    ibisobanuro2

    Ibisobanuro

    HPMC 60

    (2910)

    HPMC 65

    (2906)

    HPMC 75

    (2208)

    Ubushyuhe bwa gel (℃)

    58-64

    62-68

    70-90

    Methoxy (WT%)

    28.0-30.0

    27.0-30.0

    19.0-24.0

    Hydroxypropoxy (WT%)

    7.0-12.0

    4.0-7.5

    4.0-12.0

    Ubushyuhe (cps, 2% Igisubizo)

    3, 5, 6, 15, 50, 100, 400, 4000, 10000, 40000, 60000, 100000, 150000, 200000

    Ingano y'ibicuruzwa:

    ibisobanuro2

    Ibisobanuro

    HPMC 60

    (2910)

    HPMC 65

    (2906)

    HPMC 75

    (2208)

    Ubushyuhe bwa gel (℃)

    58-64

    62-68

    70-90

    Methoxy (WT%)

    28.0-30.0

    27.0-30.0

    19.0-24.0

    Hydroxypropoxy (WT%)

    7.0-12.0

    4.0-7.5

    4.0-12.0

    Ubushyuhe (cps, 2% Igisubizo)

    3, 5, 6, 15, 50, 100, 400, 4000, 10000, 40000, 60000, 100000, 150000, 200000

    Porogaramu

    ibisobanuro2

    Gusaba imiti igabanya ubukana bw'imiti

    HPMC yo mu rwego rwa farumasi

    Igipimo

    Ifu yo koga mu bwinshi

    75K4000,75K100000

    3-30%

    Amavuta yo kwisiga, Gel

    60E4000,75K4000

    1-5%

    Gutegura amaso

    60E4000

    01.-0.5%

    Amavuta yo mu maso

    60E4000

    0.1-0.5%

    Umukozi Ushinzwe Guhagarika

    60E4000, 75K4000

    1-2%

    Antacids

    60E4000, 75K4000

    1-2%

    Ibinini byo kubikamo ibinini

    60E5, 60E15

    0.5-5%

    Ingano y'amazi yo mu bwoko bwa "Convention Wet Granulation"

    60E5, 60E15

    2-6%

    Udupira two gupfuka ibinini

    60E5, 60E15

    0.5-5%

    Matrix yo Gusohora Igenzura

    75K100000,75K15000

    20-55%

    ibicuruzwa (1) ix8

    ibicuruzwa (2)8ux

    Imiterere y'ingenzi n'imikoreshereze ya HPMC yo mu rwego rw'imiti:

    ibisobanuro2

    1. Icyuma gifunga:

    HPMC ikora nk'ikintu gihuriza hamwe ibikoresho by'imiti (APIs) n'ibindi bikoresho biyifasha gukora ikinini gifatanye gishobora kunyobwa byoroshye.

    2. Abatandukanye:

    Hari ubwo HPMC ishobora gukoreshwa nk'umuti ugabanya ubukana bw'ibinini. Ifasha mu gusenyuka vuba kw'ibinini mo uduce duto, bigatuma umuti usohoka kandi ukinjizwa mu buryo bw'igogora.

    3. Ibikoresho byo gusiga:

    HPMC ikoreshwa nk'igikoresho cyo gutwikira ibinini na capsule, irinda umuti, ikongera uburyohe bwo guhisha, kandi ikagenzura irekurwa rya API.

    4. Gufungurwa ku buryo burambye:

    Mu miti ikoreshwa mu gupima irekurwa ry’umuti, HPMC ishobora gukoreshwa mu guhindura irekurwa ry’umuti uko igihe kigenda gihita, bigatanga ingaruka nziza ku buvuzi.

    5. Uburyo bwo guhindura ubukana bw'umuvuduko:

    Ikora nk'uburyo bwo guhindura ubushyuhe mu buryo bw'amazi n'ubudakomeye, nk'imiti ikoreshwa mu kanwa na gels zo mu bwoko bwa topical, kugira ngo igenzure imiterere n'imikorere y'amazi.

    6. Umukozi wo gusiga ifumbire:

    HPMC ishobora gukoreshwa nk'umuti utuma ifu iterwa mu buryo bwa gels zo mu kanwa n'imiti ikoreshwa mu gukamura kugira ngo yorohere kuyikoresha.

    Imikoreshereze ya HPMC yo mu rwego rwa farumasi:

    ibisobanuro2

    HPMC yo mu rwego rwa farumasi ikoreshwa cyane mu buryo butandukanye bw'imiti, harimo:

    1. Ibinini:

    Ni igice cy'ingenzi mu miterere y'ibinini, kigenzura ko ibikoresho bifatanye neza n'imiterere y'ibinyabutabire.

    2. Utudomo:

    HPMC ishobora gukoreshwa mu gukora imiti ya capsule, haba nk'ikintu gifunga ifu ndetse no mu gice cy'agasanduku ka capsule kugira ngo irekurwe cyangwa irekurwe igihe kirekire.

    3. Ibinini bitwikiriwe:

    Udupira twakozwe muri HPMC turinda ikinini kandi tukagenzura irekurwa ry'umuti.

    4. Imiti yo mu kanwa:

    Mu miterere y'amazi, HPMC ishobora gukora nk'uburyo bwo guhindura viscosity, igatuma suspension ihagarara neza.

    5. Gel n'amavuta yo kwisiga:

    Ikoreshwa mu buryo bwo gushushanya kugira ngo igere ku buryo bwifuzwa kandi buhamye.

    6. Uduce tw'imitsi:

    HPMC ishobora gukoreshwa mu gukora udukoko two mu bwoko bwa mucilage two guterwa mu kanwa.

    Ibyiza byo gukoresha HPMC yo mu rwego rwa farumasi:

    ibisobanuro2

    - Uburyo bwo gufata ibinini no kubihinduranya neza.
    - Gutanga imiti igenzurwa kugira ngo ifashe mu kuvura indwara igihe kirekire.
    - Gupfuka uburyohe no kurinda umuti mu binini bitwikiriwe.
    - Kongera imiterere n'ubudahinduka mu miterere y'amazi n'iy'ibice bikomeye.
    - Bikwiriye gukoreshwa mu buryo butandukanye bw'imiti.

    HPMC yo mu rwego rw'imiti ifite uruhare runini mu nganda z'imiti, igira uruhare mu bwiza no mu mikorere y'imiti itandukanye. Imiterere yayo ituma iba umuti ukoreshwa cyane kandi ukoreshwa cyane mu gukora ibinini, imiti ikoreshwa mu buryo bugenzurwa, n'indi miti ikoreshwa mu miti, igenzura ko imiti igira akamaro, ihamye kandi ifite umutekano ku barwayi.

    Gupfunyika

    ibisobanuro2

    Igikoresho gisanzwe cyo gupakira ni 25kg/Fiber drum
    20'FCL: toni 9 zifite pallets; toni 10 zitarashyirwamo pallets.
    40'FCL: toni 18 zifite pallets; toni 20 zitarashyirwamo pallets.

    Ububiko:

    ibisobanuro2

    Bibike ahantu hakonje kandi humutse munsi ya 30°C kandi birinzwe n'ubushuhe n'ingufu, kubera ko ibicuruzwa ari thermoplastic, igihe cyo kubibika ntikigomba kurenza amezi 36.

    Inyandiko z'umutekano:

    ibisobanuro2

    Amakuru yavuzwe haruguru ajyanye n'ibyo tuzi, ariko ntugahe abakiriya uburenganzira bwo kuyasuzuma neza ako kanya bakimara kuyakira. Kugira ngo wirinde ubwoko butandukanye bw'imiti n'ibikoresho fatizo bitandukanye, nyamuneka banza ugerageze byinshi mbere yo kuyikoresha.